A multi-institution team led by Northwestern Medicine investigators has discovered novel cellular mechanisms that lead to chemotherapy resistance in recurrent glioblastoma, according to findings published in Science Advances.

Neural stem cells (NSCs) engineered by Northwestern Medicine investigators used in combination with the HER2 inhibitor drug tucatinib improved survival in mice with HER2-positive breast cancer brain metastases, according to findings published in Proceedings of the National Academy of Sciences.

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Description goes hereNorthwestern Medicine investigators have discovered the epigenetic mechanisms involved in the regulation of multiple oncogenes in glioma cells, mechanisms that promote overall glioma tumor growth and resistance to therapy, according to a study published in the journal Clinical Cancer Research.

A novel therapy engineered by Northwestern Medicine investigators improved progression-free and overall survival for patients with newly diagnosed malignant gliomas, according to results from a recent phase I clinical trial published in The Lancet Oncology.

A drug currently used to prevent organ rejection in transplants could also reduce chemotherapy resistance in glioblastoma, according to a Northwestern Medicine study published in Brain.

A new combination therapy targeting breast cancer tumors in the brain dramatically decreased tumor size and increased survival in a study with mice, reports a new Northwestern Medicine study published in Science Translational Medicine. An estimated 75% of mice that had brain metastases from breast cancer were cured and cancer-free after the therapy.

For Shivani Baisiwala, medical school is much more than just classes and clerkships. As a rising fourth-year medical student, Baisiwala already has a wide array of experiences under her belt — from conducting basic science research into glioblastoma in the laboratory of Atique Ahmed, PhD, assistant professor of Neurological Surgery, to volunteering in free health clinics around Chicago and participating in Second Opinions, a student-run pro-bono healthcare consulting group.

A Northwestern Medicine study has demonstrated how the deadly brain cancer glioblastoma exploits dopamine in order to evade treatment and fuel growth, and suggests that targeting the neurotransmitter may slow cancer progression. . The findings were published in The Journal of Neuroscience.